Lower Circulating Cell-Free Mitochondrial DNA Is Associated with Heart Failure in Type 2 Diabetes Mellitus Patients

Cell-free nuclear (cf-nDNA) and mitochondrial (cf-mDNA) DNA are released from damaged cells in type 2 diabetes mellitus (T2DM) patients, contributing to adverse cardiac remodeling, vascular dysfunction, inflammation. The purpose of this study was correlate the presence cf-DNAs with HF T2DM patients. A total 612 patients were prescreened by using a local database, 240 (120 non-HF 120 individuals) ultimately selected. collection medical information, including both echocardiography Doppler imagery, as well assessment biochemistry parameters circulating biomarkers, performed at baseline. N-terminal brain natriuretic pro-peptide (NT-proBNP) cf-nDNA/cf-mtDNA levels measured via an ELISA kit real-time quantitative PCR tests, respectively. We found that possessed significantly higher cf-nDNA (9.9 ± 2.5 μmol/L vs. 5.4 2.7 μmol/L; p = 0.04) lower cf-mtDNA (15.7 3.3 30.4 4.8 0.001) than those without HF. multivariate log regression showed discriminative potency >7.6 (OR 1.07; 95% CI 1.03–1.12; 0.01) NT-proBNP (odds ratio [OR] 1.10; confidence interval [CI] 1.04–1.19; for In conclusion, we independently established elevated cf-nDNA, originating NT-proBNP, associated